Product Name | [Arg15, Asp16,25, Pro18,21,23, Val22, Ile24]-Amyloid b-Protein (15- |
Product Quantity | 5mg |
Catalog Number | LT0452 |
Molecular Weight | 1315.55 |
Formula | C64H94N14O16 |
Sequence | Arg-Asp-Leu-Pro-Phe-Phe-Pro-Val-Pro-Ile-Asp |
Scientific Background | [Arg15, Asp16,25, Pro18,21,23, Val22, Ile24]-Amyloid b-Protein (15- is a synthetic research peptide in the amyloid-beta family. The listed sequence/design is Arg-Asp-Leu-Pro-Phe-Phe-Pro-Val-Pro-Ile-Asp. Amyloid-beta peptides are widely used to study aggregation, oligomerization, fibril formation, sequence-dependent conformational behavior, and analytical detection relevant to Alzheimer disease research. |
Research Applications | - receptor or binding assays
- competition experiments
- enzymatic-processing studies
- antibody or antigen controls
- analytical method development
- LC-MS/HPLC reference work
- comparative structure-activity experiments
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Experimental Notes | Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally. |
Selected References | - Complete aggregation pathway of amyloid beta (1-40) and (1-42) (PMID 32285004).
- Familial Alzheimer's disease mutations differentially alter amyloid beta-protein oligomerization (PMID 23173071).
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