| Catalog Number | LT8893 |
| Product Name | Tyrosine Kinase Peptide 3, Phosphorylated |
| Product Quantity | 1 mg |
| Sequence | RRLIEDAE-pY-AARG |
| Molecular Weight | 1599.7 |
| Purity | ≥95% |
| Mechanism & Biological Significance | RRLIEDAE-pY-AARG is the phosphotyrosyl form of an Src autophosphorylation-site peptide and is a defined substrate for protein-tyrosine phosphatase studies. The pre-installed phosphotyrosine makes it chemically distinct from the corresponding unphosphorylated kinase substrate. |
| Published Research Context | Peer-reviewed phosphatase studies directly used RRLIEDAEY(P)AARG as a synthetic phosphotyrosyl substrate to measure dephosphorylation activity and substrate specificity, including work on polycation-stimulated phosphatases and receptor-like protein-tyrosine phosphatases. |
| Research Applications | - protein-tyrosine phosphatase assays
- Src-site phosphopeptide studies
- phosphotyrosine turnover measurements
- phosphatase inhibitor screening
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| Experimental Considerations | This is the phosphorylated product-state peptide. Do not treat it as equivalent to RRLIEDAEYAARG when designing kinase-versus-phosphatase experiments. |
| Selected Scientific References | - Conversion of a phosphoseryl/threonyl phosphatase into a phosphotyrosyl phosphatase
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