Transferrin Receptor Targeting Peptide

THRPPMWSPVWP is a 12-residue transferrin receptor (TfR)-binding peptide identified for receptor-targeting applications. Published studies have evaluated this sequence and radiolabeled derivatives for binding and uptake in TfR-expressing cells. The peptide provides a compact ligand for research on receptor-mediated targeting, conjugate design and cellular internalization.

• transferrin receptor targeting
• receptor-mediated uptake studies
• peptide conjugate design
• targeted delivery research

TfR expression and uptake vary by cell type. Binding and internalization of any cargo-conjugated derivative should be measured directly because conjugation can alter peptide accessibility and affinity.

1. In Vitro and Initial In Vivo Evaluation of 68Ga-Labeled Transferrin Receptor Binding Peptides