Catalog Number | LT8871 |
Product Name | [Thr28, Nle31]-Cholecystokinin (25-33), Sulfated CCK-9 |
Product Quantity | 1 mg |
Sequence | RD-Y(SO3H)-TGW-Nle-DF-NH2 |
CAS Number | 77568-41-3 |
Molecular Weight | 1251.4 |
Formula | C55H74N14O18S |
Purity | ≥95% |
Scientific Background | RD-Y(SO3H)-TGW-Nle-DF-NH2 is a stabilized sulfated CCK-9 analog containing Thr28 and norleucine at position 31. The peptide retains the sulfated tyrosine and amidated C terminus characteristic of biologically active CCK receptor ligands while replacing oxidation-sensitive methionine residues. Published conformational and receptor studies have used this analog in investigations of CCK structure, receptor binding and pancreatic signaling. |
Research Applications | - CCK receptor-binding studies
- gastrointestinal hormone research
- CCK structure-function studies
- GPCR assay development
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Experimental Notes | The Tyr sulfate, norleucine substitution and C-terminal amide are essential parts of this analog's chemical identity. It should not be treated as chemically equivalent to native sulfated CCK-8 or non-sulfated CCK peptides. |
Selected References | - Solution conformation of CCK9, a cholecystokinin analog
- Functional cholecystokinin receptors are distinguished kinetically by biotinyl-Tyr-Gly-(Thr28,Nle31)CCK(25-33)
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