TCF4 peptide

Product Name
TCF4 peptide
Product Quantity
1mg
Catalog Number
LT8238
Category
TCF4 peptide
Sequence
GGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNE-{mini-PEG}-{mini-PEG}-Lys(N3)
Purity
>95%
Product Description

Description: This peptide corresponds to a specific region of the human beta-catenin protein, encompassing amino acids 764 to 809. beta-catenin is a crucial component of the Wnt signaling pathway, playing a significant role in cell-cell adhesion and gene transcription regulation.

Applications: The peptide is utilized in biochemical assays to study protein-protein interactions, particularly the binding dynamics between beta-catenin and other cellular partners. Understanding these interactions is vital for elucidating mechanisms underlying various cellular processes and diseases, including cancer.

Biological Importance: By isolating and examining this segment of beta-catenin, researchers can gain insights into its functional domains and interaction sites. This knowledge contributes to the broader understanding of signaling pathways and may aid in the development of therapeutic strategies targeting beta-catenin-related abnormalities.

The azide is available for different dye conjugation via click chemistry. For more detailed information, please refer to the article:https://doi.org/10.1016/j.isci.2021.102544

Scientific Background

TCF4 peptide is a 45-residue synthetic peptide with the sequence Gly-Gly-Gly-Asp-Asp-Leu-Gly-Ala-Asn-Asp-Glu-Leu-Ile-Ser-Phe-Lys-Asp-Glu-Gly-Glu-Gln-Glu-Glu-Lys-Ser-Ser-Glu-Asn-Ser-Ser-Ala-Glu-Arg-Asp-Leu-Ala-Asp-Val-Lys-Ser-Ser-Leu-Val-Asn-Glu. The sequence contains 3 Lys and 1 Arg residues, contributing cationic character. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

Research Applications
  • LC-MS/HPLC analytical method development
  • sequence-specific assay controls
Experimental Notes

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.

  • 5 Units in Stock
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$950.00

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