Tax9, HTLV - 1 (11 - 19)

Product Name
Tax9, HTLV - 1 (11 - 19)
Product Quantity
4mg
Catalog Number
LT2289
Molecular Weight
1070.31
Formula
C56H79N9O12
Sequence
Leu-Leu-Phe-Gly-Tyr-Pro-Val-Tyr-Val, LLFGYPVYV. This 9-mer peptides bound with high affinity to HLA-A and displayed low dissociation rates of the bound peptide from HLA. Epitope-specific recognition was demonstrated by the release of perforin and [gamma]-interferon. This peptide demonstrate the presence of HLA class I-restricted CD8+ CTL against proteins from PE and PPE proteins of M. tuberculosis and identify epitopes that are strongly recognized by HLA-A*0201-restricted CD8+ T cells in humans. These epitopes thus represent potential subunit components for the design of vaccines against tuberculosis.
Scientific Background

Tax9, HTLV - 1 (11 - 19) is a 9-residue synthetic peptide with the sequence Leu-Leu-Phe-Gly-Tyr-Pro-Val-Tyr-Val. The sequence contains 3 aromatic residues that can contribute to hydrophobic or aromatic interactions; has a relatively high hydrophobic-residue fraction that can influence aqueous solubility and surface adsorption. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

Research Applications
  • LC-MS/HPLC analytical method development
  • sequence-specific assay controls
Experimental Notes

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.

  • 5 Units in Stock
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