Syntide 2

Syntide-2 is a synthetic peptide substrate for Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) derived from the phosphorylation site 2 in glycogen synthase. it is also a poor substrate for phosphorylase kinase and is not phosphorylated by myosin light chain kinase. The relative Vmax/Km ratios of the petide for different kinases are 100 for CaMK II. 22 for PKC. 2 for phosphorylase kinase. and 0.5 for myosin light chain kinase. respectively.

Syntide 2 is a 15-residue synthetic peptide with the sequence Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys. The sequence contains 2 Lys and 1 Arg residues, contributing cationic character. These sequence-derived properties describe the reagent chemically; no specific receptor, enzyme, pathway, disease association, or biological activity is assigned without product-specific experimental evidence.

• LC-MS/HPLC analytical method development
• sequence-specific assay controls

Sequence-derived chemical properties support reagent selection and experimental planning but do not establish biological function. Solubility, aggregation, adsorption, conjugation efficiency, and assay performance should be validated under the intended experimental conditions.