Syk Kinase Peptide Substrate, KEDPDYEWPSAK-NH2

KEDPDYEWPSAK-NH2 is a tyrosine-containing peptide substrate used for spleen tyrosine kinase (Syk) activity measurements. The central tyrosine provides the phosphoacceptor site, while the surrounding acidic and aromatic residues form a defined sequence for biochemical Syk phosphorylation assays. The peptide is useful for enzyme-activity measurements and kinase-inhibitor method development.

• Syk kinase activity assays
• tyrosine phosphorylation studies
• Syk inhibitor screening
• kinase assay development

Tyrosine phosphorylation should be measured with an assay appropriate to the intended application, such as radiometric, phosphotyrosine-binding, mass-spectrometric, or mobility-shift detection.

1. Syk kinase signaling and substrate phosphorylation research