Catalog Number | LT8891 |
Product Name | SV40 Large T-Antigen NLS Peptide |
Product Quantity | 1 mg |
Sequence | PKKKRKVEDPYC |
Molecular Weight | 1490.9 |
Formula | C66H111N19O18S |
Purity | ≥95% |
Scientific Background | PKKKRKVEDPYC is an SV40 large T-antigen nuclear localization signal (NLS)-derived peptide containing the canonical basic PKKKRKV motif plus a C-terminal PYC extension. SV40 T-antigen NLS sequences are classic model ligands for importin-dependent nuclear transport and have been used to promote nuclear localization of linked macromolecules. |
Research Applications | - nuclear localization studies
- importin-dependent transport research
- NLS-tagged cargo design
- nuclear delivery assays
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Experimental Notes | The PYC extension and terminal cysteine are part of this product sequence and can influence conjugation chemistry. Nuclear delivery of linked cargo depends on cargo size, linkage and cell context. |
Selected References | - Priming of immune responses to hepatitis B surface antigen with minimal DNA expression constructs modified with a nuclear localization signal peptide
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