Scrambled gp91ds-tat Control Peptide

YGRKKRRQRRRCLRITRQSR-NH2 is the scrambled-sequence control corresponding to the cell-permeable gp91ds-tat NADPH oxidase inhibitory peptide. It retains the Tat-derived cell-penetrating region and overall composition while rearranging the gp91phox docking sequence. The construct is used as a matched control to distinguish sequence-dependent effects of gp91ds-tat from nonspecific effects associated with peptide exposure or Tat-mediated delivery.

• gp91ds-tat control experiments
• NOX2/NADPH oxidase research
• reactive oxygen species studies
• cell-penetrating peptide controls

A scrambled peptide is a negative-control reagent rather than a guarantee of complete biological inactivity. Match concentration, vehicle, exposure time and delivery conditions to the active gp91ds-tat experiment.

1. NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by amyloid beta peptide