Catalog Number | LT8792 |
Product Name | Pyrrhocoricin Antimicrobial Peptide |
Product Quantity | 1 mg |
Sequence | VDKGSYLPRPTPPRPIYNRN |
CAS Number | 156548-23-1 |
Molecular Weight | 2340.8 |
Formula | C105H166N32O29 |
Purity | ≥95% |
Scientific Background | Pyrrhocoricin is a 20-residue proline-rich antimicrobial peptide originally isolated from the firebug Pyrrhocoris apterus. Unlike strongly membrane-lytic antimicrobial peptides, pyrrhocoricin has been shown to act intracellularly in susceptible bacteria by binding the DnaK/Hsp70 chaperone system and interfering with protein folding. Its proline-rich sequence has also been used as a scaffold for structure-activity studies aimed at improving antibacterial potency and stability. |
Research Applications | - proline-rich antimicrobial peptide research
- DnaK/chaperone interaction studies
- antibacterial structure-activity studies
- microbial growth-inhibition assays
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Experimental Notes | Pyrrhocoricin activity is species dependent and should not be generalized across all bacteria. Assay medium, ionic strength, inoculum and peptide concentration can materially affect measured antibacterial activity. |
Selected References | - Development of novel antibacterial peptides that kill resistant isolates
- Antimicrobial peptides in insects; structure and function
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