PrP (106-126), Prion Protein

PrP(106-126) is a hydrophobic fragment of human prion protein with amyloidogenic and neurotoxic properties. It is widely used as a model for prion-associated membrane perturbation, calcium signaling, oxidative responses and apoptotic mechanisms.

• neuroscience and neuropeptide research
• amyloid or receptor studies
• cell-signaling assays
• structure-function studies

Exact sequence, species, terminal chemistry and stereochemistry define this reagent. Use sequence-matched controls and consistent preparation conditions.

1. Selected peer-reviewed publication