Pramlintide

Pramlintide is a three-proline analog of human amylin engineered to reduce aggregation while retaining amylin-receptor activity. As a defined research peptide it is useful for comparing native amylin with a less amyloidogenic receptor agonist.

• calcitonin-family receptor pharmacology
• cardiovascular or metabolic signaling
• bone and calcium-homeostasis studies
• amyloid and aggregation research

N-terminal disulfide loops, C-terminal amidation, species sequence and analog substitutions are part of the exact molecular identity and can substantially change receptor activity or aggregation behavior.

1. Selected peer-reviewed publication