PKA Inhibitor Peptide PKI (6-22) Amide

PKI(6-22) amide is a potent peptide inhibitor derived from the endogenous protein kinase A inhibitor. It binds the catalytic subunit pseudosubstrate site and is a standard reagent for defining PKA-dependent signaling.

• protein kinase activity assays
• kinase inhibitor screening
• signal-transduction research
• substrate-specificity studies

Exact sequence and terminal chemistry define assay behavior. Kinase substrates should be validated under the enzyme, ATP and buffer conditions used in the specific experimental system.

1. Selected literature record