Catalog Number | LT8836 |
Product Name | Phosphothreonine Phosphatase Substrate, KR-pT-IRR |
Product Quantity | 1 mg |
Sequence | KR-pT-IRR |
Molecular Weight | 909.0 |
Formula | C34H69N16O11P |
Purity | ≥95% |
Scientific Background | KR-pT-IRR is a short phosphothreonine-containing peptide used as a serine/threonine phosphatase substrate. Its pre-installed phosphothreonine provides a defined dephosphorylation site for biochemical phosphatase assays. Published studies have used KR(pT)IRR as a synthetic phosphopeptide substrate for measuring phosphatase activity, including bacterial and mammalian phosphatases. |
Research Applications | - serine/threonine phosphatase assays
- phosphopeptide dephosphorylation studies
- phosphatase inhibitor screening
- phosphorylation-state assay controls
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Experimental Notes | This product is already phosphorylated and should be treated as a phosphatase substrate/control, not as an unphosphorylated PKC kinase substrate. Verify phosphothreonine integrity during storage and handling. |
Selected References | - Tyrosine phosphatase TpbA controls rugose colony formation in Pseudomonas aeruginosa by dephosphorylating diguanylate cyclase TpbB
- Ionizing Radiation Activates Nuclear Protein Phosphatase-1 by ATM-dependent Dephosphorylation
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