Oxytocin

Oxytocin is synthesized in the hypothalamus and involved in the control of lactation and parturition. Synthetic Human Oxytocin is a single. non-glycosylated.

Oxytocin is a synthetic research peptide in the oxytocin family. Oxytocin is a cyclic nonapeptide whose disulfide-constrained ring and C-terminal tail cooperate in receptor recognition. Oxytocin and vasopressin receptors are closely related, so sequence substitutions and conformational constraints are frequently used to alter potency and receptor selectivity. Synthetic oxytocin analogs are useful in binding, signaling, selectivity, and structure-activity studies.

• receptor-binding
• competition assays
• functional signaling assays
• enzymatic-processing or stability studies
• antibody controls
• LC-MS/HPLC method development
• comparative structure-activity experiments

For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, and stability should be considered when selecting reconstitution and assay conditions.

1. Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutic agents
2. Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs