Neurotensin (1-11)

Neurotensin (1-11) is a synthetic research peptide in the neurotensin family. Neurotensin is a 13-residue neuropeptide and hormone that signals principally through neurotensin receptors NTS1 and NTS2. Structural work established the C-terminal NT(8-13) region as the principal receptor-activating segment for NTS1. Native peptide, C-terminal fragments, and stabilized analogs are consequently used to study receptor binding, signaling, peptide metabolism, and neurotensin structure-function relationships.

• receptor-binding
• competition assays
• functional signaling assays
• enzymatic-processing or stability studies
• antibody controls
• LC-MS/HPLC method development
• comparative structure-activity experiments

For a fragment, residue-substituted analog, stereochemical variant, labeled peptide, or terminally modified form, experimental behavior should be evaluated for the exact construct rather than assumed to match the native parent peptide. Sequence-dependent solubility, aggregation, adsorption, and stability should be considered when selecting reconstitution and assay conditions.

1. Structure of the agonist-bound neurotensin receptor
2. Conjugation of a brain-penetrant peptide with neurotensin provides multifunctional analgesic agents