Neuropeptide FF Modulating Neuropeptide F-8-F-NH2

Neuropeptide FF belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus. Neuropeptide-FF(NPFF) is an FMRF-NH2-like peptide with modulating activity. NPFF is located in the central nervous system, especially in posterior pituitary and spinal cord.

Neuropeptide FF Modulating Neuropeptide F-8-F-NH2 is a synthetic research peptide in the neuropeptide FF (NPFF) family. Neuropeptide FF is an RFamide peptide that activates the G-protein-coupled receptors NPFF1 and NPFF2. Receptor cloning and functional studies established nanomolar NPFF binding and showed distinct receptor coupling and pharmacology. NPFF peptides and analogs are widely used in studies of pain modulation, opioid interactions, and RFamide receptor signaling.

• NPFF1/NPFF2 receptor binding assays
• G-protein signaling studies
• RFamide peptide structure-activity experiments
• pain-modulation research

The exact sequence, isoform, residue substitutions, amidation, stereochemistry, labels, and other chemical modifications can change activity substantially. For receptor-activating peptides and membrane-active peptides, concentration and assay format are especially important and should be matched to the intended experimental system.

1. Identification and characterization of two GPCRs for neuropeptide FF
2. Pharmacological characterization of human NPFF1 and NPFF2 receptors