Neo-Kyotorphin

Neo-Kyotorphin is a synthetic research peptide in the kyotorphin analgesic dipeptide family. Kyotorphin is the endogenous dipeptide Tyr-Arg, originally isolated from mammalian brain and characterized as an analgesic peptide. It is mechanistically distinct from classical opioid receptor agonists and has been studied for peptide-mediated analgesic signaling, membrane interaction, transport, and structure-function relationships.

• kyotorphin signaling studies
• analgesic peptide structure-function research
• membrane-interaction experiments
• Tyr-Arg analog comparisons

The exact sequence, isoform, residue substitutions, amidation, stereochemistry, labels, and other chemical modifications can change activity substantially. For receptor-activating peptides and membrane-active peptides, concentration and assay format are especially important and should be matched to the intended experimental system.

1. A novel analgesic dipeptide from bovine brain: kyotorphin
2. Membrane interactions and conformational properties of kyotorphin