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Myelin oligodendrocyte glycoprotein (MOG) 35-55 is a synthetic peptide corresponding to amino acid residues 35–55 of the extracellular domain of the MOG protein. This peptide represents a well-characterized immunodominant epitope capable of inducing T-cell mediated autoimmune responses in susceptible mouse strains.
MOG35-55 has been widely used in immunological and neurological research as a standard antigen for the induction of experimental autoimmune encephalomyelitis (EAE), a commonly employed animal model for studying the pathogenesis of multiple sclerosis (MS) and other neuroinflammatory disorders.
Due to its ability to trigger antigen-specific CD4⁺ T cell responses targeting central nervous system myelin components, the MOG35-55 peptide serves as a valuable tool for investigating autoimmune mechanisms, neuroinflammation, and therapeutic intervention strategies.
Biological Background
Myelin oligodendrocyte glycoprotein (MOG) is a minor component of the myelin sheath expressed on the outer surface of oligodendrocytes in the central nervous system. Although present in relatively low abundance, MOG is highly immunogenic and plays an important role in autoimmune responses directed against myelin.
The MOG35-55 peptide contains a key epitope recognized by T cells in several mouse models, particularly C57BL/6 mice, where it induces strong Th1 and Th17 immune responses. These immune responses lead to inflammatory demyelination and neurological symptoms resembling human multiple sclerosis.
Because of this property, the peptide has become a widely adopted reagent for studying:
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autoimmune demyelination
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antigen-specific T cell activation
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immune tolerance mechanisms
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neuroinflammatory pathways
Applications in Biomedical Research
Experimental Autoimmune Encephalomyelitis (EAE)
MOG35-55 is commonly used to induce EAE in mouse models to study multiple sclerosis pathogenesis. When administered with suitable adjuvants such as complete Freund’s adjuvant (CFA) and pertussis toxin, the peptide triggers an autoimmune response targeting myelin structures within the central nervous system.
This model enables researchers to evaluate:
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mechanisms of autoimmune demyelination
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T-cell mediated neuroinflammation
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blood–brain barrier disruption
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immune cell infiltration into the CNS
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potential therapeutic interventions
Immunology and T Cell Research
The peptide is frequently used as an antigenic stimulus to analyze antigen-specific T cell responses, particularly CD4⁺ T cells recognizing myelin epitopes. It allows researchers to study immune activation, cytokine production, and antigen presentation pathways.
Applications include:
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antigen-specific T cell activation assays
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cytokine secretion analysis (IFN-γ, IL-17)
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antigen presentation studies
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immune tolerance and regulatory T cell research
Neuroinflammation and Multiple Sclerosis Research
The MOG35-55 peptide is widely used to investigate molecular mechanisms underlying neuroinflammatory diseases and to evaluate potential treatments targeting autoimmune disorders affecting the central nervous system.
Research areas include:
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multiple sclerosis pathogenesis
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neuroimmune signaling pathways
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demyelination and remyelination mechanisms
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CNS immune cell trafficking
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evaluation of immunomodulatory therapies
Drug Discovery and Therapeutic Development
Because the MOG35-55-induced EAE model closely mimics several pathological features of multiple sclerosis, it is commonly used in preclinical studies evaluating novel therapeutic approaches.
Applications include:
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testing of immunomodulatory drugs
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monoclonal antibody development
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evaluation of immune tolerance therapies
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peptide-based therapeutic strategies
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neuroprotective compound screening
Advantages for Research Applications
MOG35-55 peptides provide several benefits for experimental studies:
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well-characterized immunodominant epitope
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reproducible induction of EAE in susceptible mouse strains
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strong antigen-specific T cell activation
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compatibility with multiple immunological assays
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widely validated model system for autoimmune research
These characteristics make MOG35-55 one of the most commonly used peptide antigens in neuroimmunology research.
Research Use Statement
This product is intended for research use only and is not approved for human or clinical use. | 