Catalog Number | LT8909 |
Product Name | LKBtide LKB1/STK11 Substrate Peptide |
Product Quantity | 1 mg |
Sequence | LSNLYHQGKFLQTFCGSPLYRRR |
Molecular Weight | 2785.4 |
Formula | C126H194N38O32S |
Purity | ≥95% |
Scientific Background | LKBtide is a synthetic peptide substrate used for serine/threonine kinase 11 (STK11/LKB1) activity measurements. The sequence was derived from the SNF1/AMPK signaling system and contains serine/threonine residues that can serve as phosphoacceptors in LKB1-dependent kinase assays. LKB1 is a major upstream regulator of the AMPK family, making LKBtide useful for biochemical studies of the LKB1-AMPK signaling axis. |
Research Applications | - LKB1/STK11 kinase activity assays
- AMPK-pathway signaling studies
- serine/threonine phosphorylation research
- kinase inhibitor and enzyme-characterization assays
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Experimental Notes | LKBtide is a synthetic assay substrate and does not reproduce the full structural context of native LKB1 targets. Assay interpretation should distinguish direct peptide phosphorylation from downstream AMPK activation. |
Selected References | - Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle
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