| Catalog Number | LT8873 |
| Product Name | [Leu31, Pro34]-Neuropeptide Y, Human/Rat |
| Product Quantity | 1 mg |
| Sequence | YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2 |
| Molecular Weight | 4240.8 |
| Purity | ≥95% |
| Mechanism & Biological Significance | [Leu31, Pro34]-NPY is a full-length amidated neuropeptide Y analog developed to distinguish Y1- from Y2-receptor pharmacology. The Leu31/Pro34 substitutions change receptor recognition while preserving the 36-residue NPY framework. |
| Published Research Context | The exact [Leu31, Pro34]NPY analog was characterized in human neuroblastoma and rat PC-12 cells. It displaced radiolabeled NPY at Y1-receptor-expressing cells but not Y2-receptor-expressing cells, produced a calcium response through Y1 signaling, and showed in vivo pressor activity in rats. |
| Research Applications | - NPY Y1 receptor pharmacology
- Y1-versus-Y2 receptor discrimination
- calcium-signaling assays
- neuropeptide structure-function studies
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| Experimental Considerations | Receptor selectivity is assay- and species-dependent; use the exact amidated analog and appropriate native-NPY controls for comparative studies. |
| Selected Scientific References | - [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist
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