JAK2 Activation-Loop Peptide

This JAK2 activation-loop sequence contains Tyr1007 and Tyr1008, key regulatory residues whose phosphorylation is associated with kinase activation. The unphosphorylated form provides a defined kinase substrate/control.

• kinase/phosphatase assays
• SH2 and SH3 interaction studies
• receptor and immune signaling
• phosphorylation-state controls

Phosphorylation state and exact motif boundaries are part of product identity. Use matched phosphorylated and nonphosphorylated sequences where quantitative comparison is required.

1. Selected literature record