Catalog Number | LT8815 |
Product Name | IRS1-Derived PI3K Binding Peptide, KKSRGDYMTMQIG-NH2 |
Product Quantity | 1 mg |
Sequence | KKSRGDYMTMQIG-NH2 |
CAS Number | 865778-50-3 |
Molecular Weight | 1513.9 |
Formula | C63H108N20O19S2 |
Purity | ≥95% |
Scientific Background | KKSRGDYMTMQIG-NH2 is an IRS1-derived peptide corresponding to the region around residues 979-989 of insulin receptor substrate-1 and contains the YMXM signaling motif. Tyrosine-phosphorylated YXXM motifs in IRS proteins recruit the SH2 domains of the p85 regulatory subunit of phosphoinositide 3-kinase (PI3K). The unphosphorylated peptide provides a sequence-defined IRS1 reagent for binding, phosphorylation and insulin-signaling assay development. |
Research Applications | - IRS1 signaling studies
- PI3K/p85 interaction assay development
- insulin-receptor pathway research
- tyrosine phosphorylation studies
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Experimental Notes | The supplied peptide is not pre-phosphorylated. High-affinity SH2-domain recognition of YXXM motifs generally depends on phosphotyrosine, so phosphorylation state should be matched to the experimental question. |
Selected References | - IRS proteins and phosphatidylinositol 3-kinase signaling
- Piceatannol inhibits adipogenesis via modulation of insulin receptor-dependent signaling
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