[Ile76]-TNF-a (70-80) (human)

[Ile76]-TNF-a (70-80) (human) is a synthetic research peptide in the TNF-alpha-derived research peptide family. TNF-alpha is a trimeric pro-inflammatory cytokine, and synthetic peptides corresponding to selected regions of TNF-alpha have been used to dissect sequence-dependent biological, receptor-related, sleep-regulatory, or immunological effects. Because short TNF fragments do not necessarily reproduce the activity of intact TNF-alpha, each residue range should be interpreted only in its specific experimental context.

• TNF-alpha fragment studies
• cytokine sequence-function research
• peptide binding experiments
• analytical or immunochemical controls

The exact sequence, residue range, stereochemistry, cyclization, terminal state, species, and chemical modifications can materially affect activity. The supplied construct should be matched to the intended assay and the specific literature context.

1. Differential effects of small TNF-alpha peptides
2. TNF-alpha as a multifunctional cytokine