Human PD-1/PD-L1 Blocking Peptide, FNWDYSWKSERLKEAYDL

FNWDYSWKSERLKEAYDL is a human PD-1-binding peptide identified in work on peptide inhibitors of the PD-1/PD-L1 protein-protein interaction. The peptide contains an aromatic WDY-centered region important to the designed binding interface and is used as a research reagent for evaluating peptide-mediated disruption of PD-1/PD-L1 binding and related immune-checkpoint assays.

• PD-1/PD-L1 binding assays
• immune-checkpoint inhibitor research
• protein-peptide interaction studies
• SPR and competition-assay development

Binding and inhibitory activity should be measured in the intended assay format; peptide potency can depend on protein construct, immobilization method, buffer, and concentration.

1. Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor