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| Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein (LTP10193) |
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| LTP10193 |
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| 100ug |
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$563 In stock |
| Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of ?IIb?3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, ?IIb?3 mediates platelet-to-platelet attachment, aggregation and clot retraction. |
| Recombinant Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein is expressed from Expi293 with His tag at the C-terminal. It contains Leu32-Arg993(ITGA2B)&GLy27-Asp718(ITGB3). |
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| Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer |
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| Human |
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| P08514-1(ITGA2B)&P05106-1(ITGB3) |
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| Leu32-Arg993(ITGA2B) & GLy27-Asp718(ITGB3) |
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| The protein has a predicted MW of 110.5 kDa (ITGA2B)&81.3 kDa (ITGB3). Due to glycosylation, the protein migrates to 95-115 kDa based on the Tris-Bis PAGE result. |
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| 0 |
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| C-His |
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| Expi293 |
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| > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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