Catalog Number | LT8816 |
Product Name | Human Collagen alpha1(I) C-Telopeptide (614-639) |
Product Quantity | 1 mg |
Sequence | SAGFDFSFLPQPPQEKAHDGGRYYRA |
Molecular Weight | 2942.4 |
Formula | C134H189N37O39 |
Purity | ≥95% |
Scientific Background | SAGFDFSFLPQPPQEKAHDGGRYYRA is a human type I collagen alpha1-chain C-telopeptide sequence used to study collagen fibrillogenesis. Synthetic C-telopeptide peptides have been shown to interfere with self-assembly of collagen I into fibrils, supporting the existence of sequence-specific binding interactions that participate in fibril formation. The peptide is therefore useful for mechanistic studies of collagen assembly, extracellular-matrix organization and telopeptide-dependent interactions. |
Research Applications | - type I collagen fibrillogenesis studies
- collagen self-assembly inhibition experiments
- extracellular-matrix research
- collagen telopeptide interaction studies
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Experimental Notes | This peptide represents a defined collagen telopeptide segment and should not be treated as equivalent to intact collagen I. Fibril-assembly effects depend on collagen concentration, temperature, ionic conditions and peptide-to-collagen ratio. |
Selected References | - Inhibition of the self-assembly of collagen I into fibrils with synthetic peptides
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