HNP-1, Human Neutrophil Defensin-1

HNP-1 is a human α-defensin stored in neutrophil azurophilic granules. Its three-disulfide fold supports broad antibacterial and antiviral activity and makes it a useful model for defensin structure, innate immunity and host-pathogen interactions.

• immunology and infectious-disease research
• T-cell or innate-immune assays
• host-pathogen interaction studies
• antimicrobial or antigen-presentation research

Exact sequence, HLA restriction, disulfide connectivity, spacer chemistry and fluorescent labeling define the reagent. Use sequence- and modification-matched controls in quantitative assays.

1. Selected peer-reviewed publication