Catalog Number | LT9004 |
Product Name | HIV-1 Tat (48-60) Cell-Penetrating Peptide |
Product Quantity | 1 mg |
Sequence | GRKKRRQRRRPPQ |
Molecular Weight | 1719.1 |
Formula | C70H131N35O16 |
Purity | ≥95% |
Scientific Background | GRKKRRQRRRPPQ corresponds to residues 48-60 of the HIV-1 Tat protein and contains the highly basic Tat protein-transduction region. Tat-derived peptides are among the most extensively studied cell-penetrating peptides and are used experimentally to deliver macromolecules and probe arginine-rich membrane-translocation mechanisms. |
Research Applications | - Tat-mediated delivery studies
- cell-penetrating peptide research
- macromolecule transport
- membrane interaction studies
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Experimental Notes | Uptake mechanism depends on concentration, cargo and cell type and can include endocytosis. Results should distinguish internalization from surface binding and endosomal retention. |
Selected References | - Interactions of cell penetrating peptide Tat with model membranes: A biophysical study
- Membrane-permeable arginine-rich peptides and the translocation mechanisms
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