Histone H4 (1-20) K5Ac

H4K5ac is a site-specific acetylated histone H4 mark enriched in transcriptionally active chromatin and newly synthesized histone pools. This free peptide is useful for deacetylase, acetyltransferase and modification-sensitive binding studies.

• H4K5 acetylation studies
• sirtuin/HDAC assays
• histone reader binding
• chromatin-state research

This is the free-acid H4(1-20) K5-acetyl form. It should not be merged with the longer H4(1-21) or H4(1-25) biotinylated K5Ac constructs.

1. Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases