Catalog Number | LT8782 |
Product Name | GSK3 Alpha/Beta Substrate Peptide, RAAVPPSPSLSRHSSPHQSEDEEE |
Product Quantity | 1 mg |
Sequence | RAAVPPSPSLSRHSSPHQSEDEEE |
Molecular Weight | 2629.9 |
Formula | C108H169N35O42 |
Purity | ≥95% |
Scientific Background | RAAVPPSPSLSRHSSPHQSEDEEE is a serine-rich synthetic peptide used as a substrate for glycogen synthase kinase 3 (GSK3) alpha and beta isoforms. The sequence contains multiple potential serine phosphorylation sites and an acidic C-terminal region, providing a defined reagent for biochemical measurements of GSK3-dependent phosphorylation and comparative kinase activity. |
Research Applications | - GSK3 alpha/beta activity assays
- serine phosphorylation studies
- GSK3 inhibitor screening
- comparative kinase assays
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Experimental Notes | Because the peptide contains several serines, phosphorylation stoichiometry and site assignment can depend on reaction conditions. Mass spectrometry or site-specific methods may be useful when phosphorylation mapping is required. |
Selected References | - Glycogen synthase kinase-3: properties, functions, and regulation
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