Glycogen Synthase (1-10), 5-FAM Labeled CaMKII Substrate

5-FAM-PLSRTLSVSS-NH2 is a fluorescent derivative of the glycogen synthase (1-10) peptide, a well-established substrate for Ca2+/calmodulin-dependent protein kinase II (CaMKII). The native decapeptide is phosphorylated in a Ca2+- and calmodulin-dependent manner, making it useful for monitoring CaMKII catalytic activity. FAM labeling adds a fluorescence handle for direct analytical detection.

• CaMKII activity assays
• Ca2+/calmodulin signaling studies
• fluorescent kinase substrate assays
• CaMKII inhibitor screening

The FAM tag is part of this product's chemical identity and can affect phosphorylation kinetics relative to unlabeled PLSRTLSVSS-NH2. Protect from light and verify assay performance for the labeled form.

1. Phosphorylation of CEACAM1 Molecule by Calmodulin Kinase IID in a Three-dimensional Model of Mammary Gland Lumen Formation
2. Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization