[Gln22]-Beta-Amyloid (1-42), E22Q Dutch Mutation

The Dutch E22Q mutation neutralizes the Glu22 charge in Aβ42 and is associated with hereditary cerebral amyloid angiopathy. The substitution accelerates aggregation in experimental Aβ42 systems.

Peer-reviewed experiments directly synthesized Aβ1-42(E22Q), verified synthetic peptide purity by chromatographic and mass-spectrometric methods, and compared its aggregation with native and other modified Aβ42 peptides.

• Dutch mutation research
• Aβ42 aggregation assays
• cerebral amyloid angiopathy studies
• mutant-versus-wild-type amyloid comparisons

Mutation identity and the Aβ C-terminal boundary are integral to this reagent. Compare with sequence-matched wild-type peptide using the same pretreatment, buffer, concentration, incubation time, and aggregation protocol.

1. Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation