GIP, Human

Glucose-dependent insulinotropic polypeptide is a 42-residue incretin hormone secreted by intestinal K cells after nutrient intake. Through GIPR it potentiates glucose-dependent insulin secretion and regulates adipose, bone and metabolic physiology.

• gastrointestinal hormone research
• incretin and metabolic signaling
• gut-brain axis studies
• GPCR and endocrine pharmacology

Exact peptide boundaries and C-terminal amidation are integral to product identity. In incretin studies, distinguish intact bioactive hormones from DPP-4-cleaved metabolites and analogs.

1. Selected peer-reviewed publication