Des-gamma-carboxylated Osteocalcin / Bone Gla Protein

Des-gamma-carboxylated osteocalcin lacks the three vitamin K-dependent Gla modifications found in fully carboxylated osteocalcin. It is useful as a substrate for gamma-glutamyl carboxylase and as a comparator in bone and endocrine studies.

• bone and calcium-homeostasis research
• GPCR and gastrointestinal hormone signaling
• affinity and receptor-binding studies
• post-translational modification research

Biotin placement, gamma-carboxylation, N-terminal pyroglutamate and C-terminal amidation define the exact reagent identity. Use sequence- and modification-matched controls in quantitative studies.

1. Selected peer-reviewed publication