|
Cys(Npys)-R9 Cell-Penetrating Peptide is an arginine-rich cell-penetrating peptide based on nona-arginine (R9), supplied with an N-terminal cysteine protected as an Npys derivative and a C-terminal amide.
Arginine-Rich Cell-Penetrating Peptides
Short oligomers of arginine are widely used as model CPPs. Their guanidinium-rich side chains interact strongly with anionic cell-surface molecules and membrane components, and they are commonly investigated for delivery of macromolecular or nanoparticle cargos.
Cys(Npys) Functional Group
The Npys-protected cysteine is a chemically activated thiol configuration that can be used in disulfide-exchange strategies. This allows an R9 CPP module to be coupled to a second thiol-containing peptide or cargo through a reducible disulfide linkage.
- CPP-cargo conjugation
- Reducible disulfide delivery constructs
- Cellular uptake studies
- Peptide translocation research
References
Futaki S, et al. Stearylated arginine-rich peptides: a new class of transfection systems. Bioconjug Chem. 2001.
doi: 10.1021/bc015508l.
Public source / publication Related LifeTein Services
Custom Peptide Synthesis
Fluorescent Peptide Labeling
Peptide Click Chemistry and Conjugation
Peptide Carrier Protein Conjugation
Research Use Only. Not for human, diagnostic, clinical, or therapeutic use.
| 