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| Cynomolgus MASP2 Protein (LTP10347) |
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| LTP10347 |
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| 100ug |
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$609 In stock |
| The dysregulation of complement cascade leads to unsolicited cytokine storm, inflammation, deterioration of alveolar lining cells, culminating in acquired respiratory destructive syndrome (ARDS). Similar pathogenesis is observed with the middle east respiratory syndrome (MERS), severe acquired respiratory syndrome (SARS), and SARS-CoV-2. Activation of the lectin pathway via mannose-binding lectin associated serine protease 2 (MASP2) is witnessed under discrete viral infections including COVID-19. |
| Recombinant Cynomolgus MASP2 Protein is expressed from E.coli with His tag at the C-terminal. It contains Thr287-Phe686. |
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| MASP2 |
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| Cynomolgus |
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| A0A2K5UJY0 |
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| Thr287-Phe686 |
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| The protein has a predicted MW of 46.8 kDa. Due to Autocatalytic cleavage, the protein migrates to 21-24 kDa&28-30 kDa based on the Tris-Bis PAGE result. |
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| Immobilized Cynomolgus MASP2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-MASP2 Antibody, hFc Tag with the EC50 of 10.4ng/ml determined by ELISA. See testing image for detail. |
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| C-His |
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| E.coli |
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| > 95% as determined by Tris-Bis PAGE |
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| Less than 1EU per ug by the LAL method. |
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| Lyophilized from 0.22 um filtered solution in 20mM Tris, 200mM NaCl (pH 9.0). Normally 8% trehalose is added as a protectant before lyophilization. |
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| Reconstituted protein stable at -80 C for 12 months, 4 C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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| Shipped at ambient temperature. |
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| Centrifuge tubes before opening. Reconstituting to a concentration of more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
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