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FSRSLHSLL is a 9-amino acid peptide derived from the Nur77 protein, also known as NR4A1. This peptide sequence is integral to the chimeric proapoptotic peptide D-NuBCP-9-R8, which combines the Nur77-derived sequence with the cell-penetrating peptide octaarginine (R8) to facilitate intracellular delivery and induce apoptosis in cancer cells. The N-terminal phenylalanine (F) in FSRSLHSLL plays a crucial role in enhancing peptide uptake and cytotoxicity. Studies have shown that the presence of this phenylalanine synergizes with R8 to increase cellular uptake at low nontoxic levels and induce rapid membrane blebbing and cell necrosis at higher concentrations.
Given its origin from Nur77, FSRSLHSLL may have applications in the following areas:
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Cancer Therapy: As part of the D-NuBCP-9-R8 peptide, it can be used to induce apoptosis in cancer cells by targeting Bcl-2 family proteins.
- Drug Delivery Systems: The peptide's sequence can be utilized in designing drug delivery systems that exploit its ability to penetrate cell membranes.
- Biomarker Development: Due to its specific sequence, it may serve as a biomarker in studies related to apoptosis and cancer research.
For researchers interested in the biological activities of Nur77-derived peptides, FSRSLHSLL offers a valuable tool for exploring apoptosis mechanisms and developing therapeutic strategies.
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