Product Name | Calcitonin Gene Related Peptide (8-37), human |
Product Quantity | 5mg |
Catalog Number | LT1180 |
Molecular Weight | 3125.65 |
Formula | C139H230N44O38 |
Sequence | Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 |
Product Description | Calcitonin gene related peptide (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms, a-CGRP and ß-CGRP. a-CGRP is a 37-amino acid peptide and is formed from the alternative splicing of the calcitonin/CGRP gene located on chromosome 11. The less-studied ß-CGRP differs in three amino acids (in humans) and is encoded in a separate gene in the same vicinity. CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. |
Scientific Background | Calcitonin Gene Related Peptide (8-37), human is a synthetic research peptide in the calcitonin gene-related peptide (CGRP) family. CGRP is a 37-residue neuropeptide. Removal of the first seven residues produces CGRP(8-37), a widely used competitive CGRP-receptor antagonist, making full-length and truncated CGRP reagents useful for receptor and vascular pharmacology. |
Research Applications | - CGRP receptor assays
- agonist-antagonist comparisons
- vascular signaling studies
- CGRP fragment structure-activity studies
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Experimental Notes | The exact sequence, residue range, species, terminal state, and chemical modifications should be matched to the intended assay. Fragmentation or processing can materially alter receptor selectivity, potency, aggregation, or enzymatic behavior. |
Selected References | - Human alpha-CGRP(8-37) as a CGRP antagonist
- Peptide antagonists of the CGRP receptor
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