Product Name | Calcitonin Gene Related Peptide (8-37), rat |
Product Quantity | 5mg |
Catalog Number | LT1181 |
Molecular Weight | 3127.58 |
Formula | C138H224N42O41 |
Sequence | Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 |
Product Description | This is amino acids 8 to 37 fragment of the rat calcitonin. It shows high binding to lung membranes. Binding activity of this peptide is even stronger than the full length CGRP peptide. Calcitonin-Gene-Related Peptide (CGRP)(8-37) inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats. |
Scientific Background | Calcitonin Gene Related Peptide (8-37), rat is a synthetic research peptide in the calcitonin gene-related peptide (CGRP) family. CGRP is a 37-residue neuropeptide. Removal of the first seven residues produces CGRP(8-37), a widely used competitive CGRP-receptor antagonist, making full-length and truncated CGRP reagents useful for receptor and vascular pharmacology. |
Research Applications | - CGRP receptor assays
- agonist-antagonist comparisons
- vascular signaling studies
- CGRP fragment structure-activity studies
|
Experimental Notes | The exact sequence, residue range, species, terminal state, and chemical modifications should be matched to the intended assay. Fragmentation or processing can materially alter receptor selectivity, potency, aggregation, or enzymatic behavior. |
Selected References | - Human alpha-CGRP(8-37) as a CGRP antagonist
- Peptide antagonists of the CGRP receptor
|
