Biotin-(Arg)9 Cell-Penetrating Peptide

Biotin-LC-RRRRRRRRR-NH2 is a biotinylated nona-arginine cell-penetrating peptide. Oligoarginine peptides are widely used as compact cationic delivery sequences, while the biotin-LC group provides an affinity handle for streptavidin-based capture, immobilization and detection. This reagent is suitable for studies that combine arginine-rich membrane translocation with biotin-based analytical workflows.

• oligoarginine cell-penetration studies
• streptavidin capture assays
• cargo-delivery research
• biotinylated peptide interaction studies

Biotin-LC labeling changes mass and surface properties relative to unmodified Arg9. Cellular uptake and binding should therefore be validated for this labeled construct.

1. Cell-penetrating peptides: 20 years later, where do we stand?