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This peptide contains multiple repeats of the RGD (Arg-Gly-Asp) motif, which is recognized by integrins, a family of cell surface receptors involved in cell adhesion and signaling. The RGD sequence is commonly found in extracellular matrix (ECM) proteins such as fibronectin, vitronectin, and fibrinogen, and plays a crucial role in mediating cell attachment to these matrices.
The PPPPRGDRGDRGD peptide is utilized in various biomedical and research applications:
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Cell Adhesion Studies: Investigating how cells interact with ECM proteins and the role of integrins in these processes.
- Tissue Engineering: Incorporating into biomaterials to enhance cell attachment and proliferation, which is crucial for tissue engineering and regenerative medicine.
- Drug Delivery: Targeting drugs to specific cells, particularly in cancer therapy, by exploiting the overexpression of certain integrins on tumor cells.
- Diagnostic Imaging: Conjugating with imaging agents to visualize tumors and other pathological conditions where integrins are overexpressed.
- Wound Healing: Promoting cell migration and tissue repair by enhancing cell adhesion at wound sites.
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