Big Endothelin-1 (1-38), Human

Big Endothelin-1 is the 38-residue precursor converted by endothelin-converting enzymes to mature ET-1. It is a useful substrate for ECE activity assays and for studying endothelin biosynthesis and vascular peptide processing.

• cardiovascular and vascular signaling
• GPCR/receptor pharmacology
• endothelial and angiogenesis research
• peptide-processing studies

Disulfide connectivity, C-terminal amidation and exact precursor boundaries are integral to biological activity. Preserve the specified molecular form when comparing receptor or enzyme assays.

1. Selected peer-reviewed publication