Beta-Amyloid (1-42), rat

β-Amyloid production results from cleavage in the extracellular domain of APP by the β-secretase , which results in the production of the APP C-terminal fragment C99. This fragment is further cleaved by the γ-secretase at residues 40-42 to produce β-amyloid 40 and 42 peptides. β-amyloid aggregation and neuritic plaque formation are pathologic hallmarks of AD.