Beta-Amyloid (1-42), HCl Salt

Aβ42 is the highly aggregation-prone 42-residue amyloid-β species central to Alzheimer disease research. Defined salt form and sample preparation materially affect assembly behavior.

A peer-reviewed β-sheet-breaker study explicitly reports purchasing Aβ1-42 HCl salt from the commercial supplier and directly used that exact commercial form in fibrillogenesis and electrophysiological experiments.

• Aβ42 fibrillogenesis
• amyloid inhibitor screening
• electrophysiological neurotoxicity experiments
• counterion/formulation comparisons

The hydrochloride counterion is part of the exact reagent identity. Use matched salt forms when comparing fibrillogenesis, electrophysiology or inhibitor effects.

1. A novel β-sheet breaker, RS-0406, reverses amyloid β-induced cytotoxicity and impairment of long-term potentiation in vitro