Beta-Amyloid (11-42), pyroGlu11

Pyroglutamate Aβ11-42 contains a cyclized N-terminal Glu11. This post-translational modification changes charge and stability and represents a distinct truncated Aβ species relevant to Alzheimer disease amyloid heterogeneity.

• amyloid-beta aggregation research
• Alzheimer disease research
• sequence/control studies
• biochemical assay development

Exact fragment boundaries, sequence order and N-terminal chemistry can materially alter Aβ solubility, aggregation and recognition. Treat this construct as a distinct reagent and use matched controls.

1. Pyroglutamate and isoaspartate modified amyloid-beta in ageing and Alzheimer's disease