[Asp371] Tyrosinase(369-377), human

[Asp371] Tyrosinase(369-377), human is a synthetic tyrosinase-derived melanoma antigen peptide. Tyrosinase is a melanocyte differentiation antigen from which multiple MHC-restricted T-cell epitopes have been identified. Synthetic tyrosinase peptides have been used to induce and measure peptide-specific cytotoxic T cells, map HLA class I and class II determinants, and investigate the effects of naturally occurring residue modifications on immune recognition. The relevance of an individual peptide depends on its exact residue range and HLA context.

• melanoma antigen-specific T-cell assays
• HLA class I or II peptide-binding studies
• CTL epitope mapping
• antigen-processing research
• native-versus-modified peptide comparisons

For antigenic or viral peptides, HLA restriction, cellular response, and immunological activity should not be inferred solely from the source protein name; the exact sequence, residue numbering, strain or genotype, and experimental system should be considered. For labeled or otherwise modified variants, the modification may also affect binding or assay behavior.

1. Human melanoma patients recognize an HLA-A1-restricted tyrosinase CTL epitope
2. Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line