Alpha-Tubulin (29-50) Lys40-Acetyl Peptide, Biotinylated

This alpha-tubulin fragment contains acetyl-Lys40, an established microtubule post-translational modification, plus a C-terminal biotin capture handle. The defined peptide supports biochemical studies of tubulin acetylation, deacetylase recognition and modification-selective binding reagents.

• HDAC6 and SIRT2 deacetylase studies
• Alpha-tubulin Lys40-acetyl antibody evaluation
• Streptavidin capture and pull-down assays
• Tubulin post-translational-modification research

The peptide models a local modified tubulin sequence and does not reproduce the architecture of a soluble tubulin dimer or assembled microtubule. Enzyme behavior can differ between peptide, dimeric and polymerized substrates.

1. HDAC6 inhibition and tubulin acetylation in intracellular transport
2. HDAC6 preference for tubulin substrates
3. SIRT2-dependent alpha-tubulin deacetylation