Adrenomedullin (1-52), human

Adrenomedullin (1-52), human is a synthetic research peptide in the adrenomedullin family. The listed sequence/design is Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2?Disulfide bridge Cys16-Cys21?. Adrenomedullin is a calcitonin-family peptide whose receptor complexes contain CLR with receptor-activity-modifying proteins, particularly RAMP2 for AM1 receptor pharmacology.

• receptor or binding assays
• competition experiments
• enzymatic-processing studies
• antibody or antigen controls
• analytical method development
• LC-MS/HPLC reference work
• comparative structure-activity experiments

Because this product may be a fragment, substituted analog, stereochemical variant, or terminally modified form, its activity should not be assumed to be identical to the native parent peptide. Peptide solubility, aggregation, adsorption to surfaces, and stability can vary with sequence, concentration, pH, ionic strength, and terminal modifications, so assay-specific reconstitution and storage conditions should be validated experimentally.

1. Enhanced vascular responses to adrenomedullin with RAMP2 overexpression (PMID 16373602).
2. Selective CGRP and adrenomedullin binding by RAMP-CLR extracellular domains (PMID 24115156).